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8 research outcomes, page 1 of 1
  • publication . Article . 2007
    Open Access
    Authors:
    Yong Guo; Christine Korteweg; Michael A. McNutt; Jiang Gu;
    Publisher: Elsevier BV

    Severe acute respiratory syndrome (SARS) is an acute respiratory disease with significant morbidity and mortality. While its clinical manifestations have been extensively studied, its pathogenesis is not yet fully understood. A limited number of autopsy studies have rev...

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  • publication . Article . 2015
    Open Access
    Authors:
    Ben Berkhout; Formijn J. van Hemert;
    Project: NWO | Molecular RNA switches th... (2300159945)

    Highlights • The nucleotide composition of a coronaviral RNA genome is biased (high U, low C). • This bias is a relatively stable property along the viral genome, but less prominent in the last 1/3 of the genome. • This bias is even more pronounced in the single-strande...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Prashant Khare; Utkarsha Sahu; Satish Chandra Pandey; Mukesh Samant;
    Persistent Identifiers
    Publisher: Published by Elsevier B.V.

    Graphical abstract

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  • publication . Other literature type . Article . 2015
    Open Access
    Authors:
    Hui-Ju, Han; Hong-ling, Wen; Chuan-Min, Zhou; Fang-Fang, Chen; Li-Mei, Luo; Jian-wei, Liu; Xue-Jie, Yu;
    Publisher: Elsevier BV

    Highlights • Bats has been considered as natural reservoirs of several highly pathogenic viruses, including Ebola virus, SARS-CoV, MERS-CoV, Nipah virus, and Hendra viruses. • Social, biological and immunological features of bats play an important role in virus maintena...

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  • publication . Article . 2012
    Open Access English
    Authors:
    Min Ke; Yu Chen; Andong Wu; Ying Sun; Ceyang Su; Hao Wu; Xu Jin; Jiali Tao; Yi Wang; Xiao Ma; ...
    Publisher: Elsevier B.V.

    Coronaviruses are the etiological agents of respiratory and enteric diseases in humans and livestock, exemplified by the life-threatening severe acute respiratory syndrome (SARS) caused by SARS coronavirus (SARS-CoV). However, effective means for combating coronaviruses...

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  • publication . Article . Other literature type . 2008
    Open Access English
    Authors:
    Cameron, Mark J.; Bermejo-Martin, Jesus F.; Danesh, Ali; Muller, Matthew P.; Kelvin, David J.;
    Publisher: Elsevier B.V.
    Project: CIHR

    Progressive immune-associated injury is a hallmark of severe acute respiratory syndrome (SARS). Viral evasion of innate immunity, hypercytokinemia and systemic immunopathology in the SARS coronavirus (SARS CoV) infected host have been suggested as possible mechanisms fo...

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  • publication . Article . 2004
    Open Access English
    Authors:
    Wanjun Gu; Tong Zhou; Jianmin Ma; Xiao Sun; Zuhong Lu;
    Publisher: Elsevier B.V.

    In this study, we calculated the codon usage bias in severe acute respiratory syndrome Coronavirus (SARSCoV) and performed a comparative analysis of synonymous codon usage patterns in SARSCoV and 10 other evolutionary related viruses in the Nidovirales. Although there i...

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  • publication . Article . 2013
    Open Access
    Authors:
    Xu Jin; Yu Chen; Ying Sun; Cong Zeng; Yi Wang; Jiali Tao; Andong Wu; Xiao Yu; Zhou Zhang; Jie Tian; ...
    Publisher: Elsevier BV

    Highlights • We found SARS-CoV nsp14 could methylate GTP and dGTP. • Critical residues of nsp14 essential for the activity on GTP were identified. • m7GTP or nsp14 could interfere with protein translation.

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8 research outcomes, page 1 of 1