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7 research outcomes, page 1 of 1
  • publication . Article . 2007
    Open Access
    Authors:
    Gary P. Kobinger; Joanita Figueredo; Thomas Rowe; Yan Zhi; Guangping Gao; Julio Sanmiguel; Peter Bell; Nelson A. Wivel; Lois A. Zitzow; Douglas B. Flieder; ...
    Publisher: Elsevier BV

    A ferret model of severe acute respiratory syndrome (SARS)-CoV infection was used to evaluate the efficacy of an adenovirus vaccine. Animals were subjected to heterologous prime-boost using vectors from human serotype 5 and chimpanzee derived adenoviruses (human AdHu5 a...

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  • publication . Other literature type . Article . 2008
    Open Access
    Authors:
    Liniger, Matthias; Zuniga, Armando; Tamin, Azaibi; Azzouz-Morin, Teldja N.; Knuchel, Marlyse; Marty, Rene R.; Wiegand, Marian; Weibel, Sara; Kelvin, David; Rota, Paul A.; ...
    Publisher: Elsevier BV
    Project: NIH | NEW LIVE VIRAL VECTORS AS... (5P01AI046007-05)

    Summary Live attenuated recombinant measles viruses (rMV) expressing a codon-optimised spike glycoprotein (S) or nucleocapsid protein (N) of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) were generated (rMV-S and rMV-N). Both recombinant viruses st...

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  • publication . Article . 2007
    Open Access
    Authors:
    Mary C. Hu; Taff Jones; Richard T. Kenney; Dale L. Barnard; David S. Burt; George H. Lowell;
    Publisher: Elsevier BV
    Project: NIH | Development of Proteosome... (1UC1AI062600-01)

    The feasibility of developing a prophylactic vaccine against SARS was assessed by comparing the immune responses elicited by immunizing mice with a recombinant SARS spike glycoprotein (S-protein) formulated with different adjuvants, given by different routes. In both yo...

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  • publication . Article . 2005
    Open Access
    Authors:
    Jiansan Zhang; Yuxuan Liu; Liangxiang Hu; Qiang Gao; Zhenshan Zhang; Xiao-Mei Zhang; Jiang-Ting Chen; Xuejie Gong; Li-Fei Song; Yufen Liu; ...
    Publisher: Elsevier BV

    A reference antiserum for SARS is in urgent need in the development of SARS vaccine and other serological test of SARS research. Convalescent serum was collected from clinical confirmed patient. ELISA, Western-blotting and neutralization assay detected specific antibody...

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  • publication . Other literature type . Article . 2005
    Open Access
    Authors:
    Czub, Markus; Weingartl, Hana; Czub, Stefanie; He, Runtao; Cao, Jingxin;
    Publisher: Elsevier BV

    Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) remains a threat to cause epidemics as evidenced by recent sporadic cases in China. In this communication, we evaluated the efficacy and safety of two SARS vaccine candidates ba...

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  • publication . Article . 2005
    Open Access English
    Authors:
    Marc Girard; Thomas Cherian; Yuri Pervikov; Marie Paule Kieny;
    Publisher: Published by Elsevier Ltd.

    Worldwide, acute respiratory infections (ARIs) constitute the leading cause of acute illnesses, being responsible for nearly 4 million deaths every year, mostly in young children and infants in developing countries. The main infectious agents responsible for ARIs includ...

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  • publication . Article . 2008
    Open Access
    Authors:
    Kai Schulze; Caroline Staib; Hermann M. Schätzl; Thomas Ebensen; Volker Erfle; Carlos A. Guzmán;
    Publisher: Elsevier BV

    Severe acute respiratory syndrome (SARS) is a serious infectious disease caused by the SARS coronavirus. We assessed the potential of prime-boost vaccination protocols based on the nucleocapsid (NC) protein co-administered with a derivative of the mucosal adjuvant MALP-...

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7 research outcomes, page 1 of 1