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48 research outcomes, page 1 of 5
  • publication . Article . 2009
    Open Access English
    Authors:
    Kamitani, Wataru; Huang, Cheng; Narayanan, Krishna; Lokugamage, Kumari G.; Makino, Shinji;
    Persistent Identifiers
    Project: NIH | Analysis of SARS Coronavi... (5R01AI072493-03)

    Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression, including type I interferon production, by promoting host mRNA degradation and inhibiting host translation, in infected cells. We present evidence that nsp1 uses a novel, two-pro...

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  • publication . Other literature type . Doctoral thesis . 2013
    Open Access English
    Authors:
    Brand, Judith;
    Persistent Identifiers
    Publisher: Unpublished
    Project: EC | EMPERIE (223498), EC | ADITEC (280873), NIH | JOINT SCHOOL SYSTEM AND U... (5H86SP002004-05)

    textabstractIn humans, viral infections causing respiratory disease have been known for many years. Every now and then such viruses may cause epidemics involving large groups of people or even pandemics with spread across the world. At the end of last century and at the...

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  • publication . Article . 2018
    Open Access
    Authors:
    Webb, Stacy R.; Smith, Stacy E.; Fried, Michael G.; Dutch, Rebecca Ellis;
    Persistent Identifiers
    Publisher: American Society for Microbiology
    Project: NIH | SV5 and Hendra virus F pr... (1R01AI051517-01), NIH | Genetic Technologies Core (1P30GM110787-01), NIH | Fusion protein TM-TM inte... (1F31AI120653-01)

    ABSTRACT Enveloped viruses require viral fusion proteins to promote fusion of the viral envelope with a target cell membrane. To drive fusion, these proteins undergo large conformational changes that must occur at the right place and at the right time. Understanding the...

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  • publication . Article . 2005
    Open Access English
    Authors:
    Baranov, Pavel V.; Henderson, Clark M.; Anderson, Christine B.; Gesteland, Raymond F.; Atkins, John F.; Howard, Michael T.;
    Persistent Identifiers
    Publisher: Elsevier Inc.
    Project: NIH | RECODING--DYNAMIC REPROGR... (2R01GM048152-05A1)

    AbstractProgrammed ribosomal frameshifting is an essential mechanism used for the expression of orf1b in coronaviruses. Comparative analysis of the frameshift region reveals a universal shift site U_UUA_AAC, followed by a predicted downstream RNA structure in the form o...

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  • publication . Article . Other literature type . 2008
    Open Access
    Authors:
    Mossel, Eric C.; Wang, Jieru; Jeffers, Scott; Edeen, Karen E.; Wang, Shuanglin; Cosgrove, Gregory P.; Funk, C. Joel; Manzer, Rizwan; Miura, Tanya A.; Pearson, Leonard D.; ...
    Persistent Identifiers
    Publisher: Elsevier BV
    Project: NIH | Alveolar Type II Cells in... (5R01HL029891-24), NIH | Type II Pneumocyte Intera... (5P01AI059576-05)

    AbstractSevere acute respiratory syndrome (SARS) is a disease characterized by diffuse alveolar damage. We isolated human alveolar type II cells and maintained them in a highly differentiated state. Type II cell cultures supported SARS-CoV replication as evidenced by RT...

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  • publication . Article . Preprint . 2021
    Open Access English
    Authors:
    Feng, Song; Heath, Emily; Jefferson, Brett; Joslyn, Cliff; Kvinge, Henry; Mitchell, Hugh D.; Praggastis, Brenda; Eisfeld, Amie J.; Sims, Amy C.; Thackray, Larissa B.; ...
    Persistent Identifiers
    Publisher: BioMed Central
    Project: NIH | Systems Biology Analysis ... (5U19AI106772-03)

    Background Representing biological networks as graphs is a powerful approach to reveal underlying patterns, signatures, and critical components from high-throughput biomolecular data. However, graphs do not natively capture the multi-way relationships present among gene...

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  • publication . Article . Other literature type . 2013
    Open Access English
    Authors:
    Carmina Verdiá-Báguena; Jose L. Nieto-Torres; Antonio Alcaraz; Marta L. DeDiego; Luis Enjuanes; Vicente M. Aguilella;
    Publisher: Elsevier B.V.
    Project: EC | EMPERIE (223498), NIH | PPG: SARS-CoV-host cell i... (2P01AI060699-06A1)

    This work was supported by grants from the Ministry of Science and Innovation of Spain (MICINN. FIS2010-19810, BIO2007-60978 and BIO2010-16705), Fundació Caixa Castelló-Bancaixa (P1-1B2012-03), Generalitat Valenciana (Prometeu/2012/069), the European Community's Seventh...

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  • publication . Article . Other literature type . 2007
    Open Access English
    Authors:
    Daniel H. Libraty; Kimberly M. O'Neil; Lauren M. Baker; Luz P. Acosta; Remigio M. Olveda;
    Persistent Identifiers
    Publisher: Elsevier Inc.
    Project: NIH | Cellular Immunity to Cate... (5U19AI057319-03), NIH | Cellular Immune Response ... (1R21AI060791-01)

    Little is known about CD4(+) T-cell immunity to the severe acute respiratory syndrome (SARS) coronavirus. In two SARS patients, we examined the memory CD4(+) T-cell responses to peptides derived from SARS coronavirus structural proteins. We generated CD4(+) T-cell lines...

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  • publication . Other literature type . Article . 2013
    Open Access English
    Authors:
    Ewan P. Plant; Amy C. Sims; Ralph S. Baric; Jonathan D. Dinman; Deborah R. Taylor;
    Publisher: Multidisciplinary Digital Publishing Institute
    Project: NIH | Characterization of the S... (5R01AI064307-05)

    In previous studies, differences in the amount of genomic and subgenomic RNA produced by coronaviruses with mutations in the programmed ribosomal frameshift signal of ORF1a/b were observed. It was not clear if these differences were due to changes in genomic sequence, t...

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  • publication . Article . 2008
    Open Access English
    Authors:
    Yunxin Chen; Li Liu; Qiang Wei; Hua Zhu; Hong Jiang; Xinming Tu; Chuan Qin; Zhiwei Chen;
    Persistent Identifiers
    Publisher: Elsevier Inc.
    Project: NIH | A Novel Model for the Stu... (1R01HL080211-01), NIH | A Novel Model for the Stu... (5R01HL080211-03)

    None: Angiotensin converting enzyme 2 (ACE2) is the receptor that severe acute respiratory syndrome coronavirus (SARS-CoV) utilizes for target cell entry and, therefore, plays an important role in SARS pathogenesis. Since Chinese rhesus (rh) macaques do not usually deve...

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48 research outcomes, page 1 of 5