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The following results are related to COVID-19. Are you interested to view more results? Visit OpenAIRE - Explore.
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19 research outcomes, page 1 of 2
  • publication . Article . 2009
    Open Access English
    Authors:
    Kamitani, Wataru; Huang, Cheng; Narayanan, Krishna; Lokugamage, Kumari G.; Makino, Shinji;
    Persistent Identifiers
    Project: NIH | Analysis of SARS Coronavi... (5R01AI072493-03)

    Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression, including type I interferon production, by promoting host mRNA degradation and inhibiting host translation, in infected cells. We present evidence that nsp1 uses a novel, two-pro...

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  • publication . Article . 2005
    Open Access English
    Authors:
    Imai, T.; Takahashi, K.; Hoshuyama, T.; Hasegawa, N.; Lim, M. -K; David Koh;
    Persistent Identifiers
    Publisher: Centers for Disease Control and Prevention

    In coping with severe acute respiratory syndrome (SARS), infection control measures are a key aspect of protecting healthcare workers. We conducted a survey concerning perception of risk and countermeasures for SARS in 7 tertiary hospitals in Japan from July through Sep...

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  • publication . Article . 2006
    Open Access
    Authors:
    Tetsuya Mizutani; Shuetsu Fukushi; Koji Ishii; Yuko Sasaki; Tsuyoshi Kenri; Masayuki Saijo; Yumi Kanaji; Kinji Shirota; Ichiro Kurane; Shigeru Morikawa;
    Persistent Identifiers
    Publisher: Elsevier BV

    Previously, we reported the establishment of cells with persistent SARS-CoV infection after apoptotic events and showed that both JNK and PI3K/Akt signaling pathways are important for persistence by treatment with inhibitors at the early stages of SARS-CoV infection. Ho...

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  • publication . Article . 2004
    Open Access English
    Authors:
    Sheng Xiong; Wang Yifei; Mei-Ying Zhang; Xinjian Liu; Chuan-hai Zhang; Shi-Sheng Liu; Chuiwen Qian; Jiu-Xiang Li; Jiahai Lu; Zhuo-Yue Wan; ...
    Persistent Identifiers
    Publisher: Elsevier B.V.

    Severe acute respiratory syndrome (SARS) is a serious infectious threat to public health. To create a novel trial vaccine and evaluate its potency, we attempted to generate a SARS inactivated vaccine using SARS coronavirus (SARS-CoV) strain F69 treated with formaldehyde...

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  • publication . Article . 2006
    Open Access
    Authors:
    Teppei Imai; Ken Takahashi; Tsutomu Hoshuyama; Naoki Hasegawa; Sin Eng Chia; David Koh;
    Persistent Identifiers
    Publisher: Elsevier BV

    Emergency infection control measures are essential in hospitals. Although Japan was spared from the 2003 epidemic of severe acute respiratory syndrome (SARS), hospitals were placed on high alert. The actual preparedness level of hospitals can be determined by examining ...

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  • publication . Article . 2013
    Open Access
    Authors:
    Pillaiyar Thanigaimalai; Sho Konno; Takehito Yamamoto; Yuji Koiwai; Akihiro Taguchi; Kentaro Takayama; Fumika Yakushiji; Kenichi Akaji; Shen En Chen; Aurash Naser-Tavakolian; ...
    Persistent Identifiers
    Publisher: Elsevier BV
    Project: NSF | Inhibition of Protein-Pro... (1157506), NIH | STRUCTURE BASED THERMODYN... (3R01GM057144-06S1), NIH | Structure-Based Antagonis... (3P01GM056550-16S1)

    We report the design and synthesis of a series of dipeptide-type inhibitors with novel P3 scaffolds that display potent inhibitory activity against SARS-CoV 3CLpro. A docking study involving binding between the dipeptidic lead compound 4 and 3CLpro suggested the modific...

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  • publication . Article . 2006
    Open Access
    Authors:
    Koji Ishii; Hideki Hasegawa; Noriyo Nagata; Tetsuya Mizutani; Shigeru Morikawa; Tetsuro Suzuki; Fumihiro Taguchi; Masato Tashiro; Toshitada Takemori; Tatsuo Miyamura; ...
    Persistent Identifiers
    Publisher: Elsevier BV

    AbstractSARS-coronavirus (SARS-CoV) has recently been identified as the causative agent of SARS. We constructed a series of recombinant DIs (rDIs), a highly attenuated vaccinia strain, expressing a gene encoding four structural proteins (E, M, N and S) of SARS-CoV indiv...

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  • publication . Article . 2012
    Open Access
    Authors:
    Shumpei Tsuda; Shumpei Watanabe; Joseph S. Masangkay; Tetsuya Mizutani; Phillip A. Alviola; Naoya Ueda; Koichiro Iha; Satoshi Taniguchi; Hikaru Fujii; Kentaro Kato; ...
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC

    Bat coronavirus (BtCoV) is assumed to be a progenitor of severe acute respiratory syndrome (SARS)-related coronaviruses. To explore the distribution of BtCoVs in the Philippines, we collected 179 bats and detected viral RNA from intestinal or fecal samples by RT-PCR. Th...

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  • publication . Article . 2013
    Open Access English
    Authors:
    Pillaiyar Thanigaimalai; Sho Konno; Takehito Yamamoto; Yuji Koiwai; Akihiro Taguchi; Kentaro Takayama; Fumika Yakushiji; Kenichi Akaji; Yoshiaki Kiso; Yuko Kawasaki; ...
    Persistent Identifiers
    Publisher: Elsevier Masson SAS.
    Project: NIH | STRUCTURE BASED THERMODYN... (3R01GM057144-06S1)

    Graphical abstract

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  • publication . Article . 2005
    Open Access English
    Authors:
    Masayuki Saijo; Shigeru Morikawa; Shuetsu Fukushi; Tetsuya Mizutani; Hideki Hasegawa; Noriyo Nagata; Naoko Iwata; Ichiro Kurane;
    Publisher: Elsevier B.V.

    The activity of inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors, mizoribine and ribavirin, against severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) was determined by plaque reduction and yield reduction assays. Mizoribine and ribaviri...

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19 research outcomes, page 1 of 2