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116 research outcomes, page 1 of 12
  • publication . Article . 2005
    Open Access English
    Authors:
    Meng, B.; Wang, J.; Liu, J.; Wu, J.; Zhong, E.;
    Persistent Identifiers
    Publisher: The Royal Institute of Public Health. Published by Elsevier Ltd.

    Summary Objectives To measure the spatial contagion of severe acute respiratory syndrome (SARS) in Beijing and to test the different epidemic factors of the spread of SARS in different periods. Methods A join-count spatial statistic study was conducted and the given hyp...

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  • publication . Article . 2004
    Open Access English
    Authors:
    Shan, Yu-Fei; Li, Shou-Feng; Xu, Gen-Jun;
    Persistent Identifiers
    Publisher: Elsevier Inc.

    The 3C-like protease (3CLpro) of severe acute respiratory syndrome (SARS) has been proposed as an attractive target for drug design. His41 and Cys145 were essential for the active site as the principal catalytic residues. In this study, we mutated the two sites, express...

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  • publication . Article . 2013
    Open Access English
    Authors:
    Cheng, Vincent C.C.; Chan, Jasper F.W.; To, Kelvin K.W.; Yuen, K.Y.;
    Persistent Identifiers
    Publisher: The Authors. Published by Elsevier B.V.

    AbstractThe outbreak of severe acute respiratory syndrome (SARS) in 2003 was the first emergence of an important human pathogen in the 21st century. Responding to the epidemic provided clinicians with extensive experience in diagnosing and treating a novel respiratory v...

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  • publication . Article . 2010
    Open Access
    Authors:
    Danesh, Ali; Cameron, Cheryl M.; León, Alberto J.; Ran, Longsi; Xu, Luoling; Fang, Yuan; Kelvin, Alyson A.; Rowe, Thomas; Chen, Honglin; Guan, Yi; ...
    Persistent Identifiers
    Publisher: Elsevier BV

    Type I interferons (IFNs) are essential to the clearance of viral diseases, however, a clear distinction between genes upregulated by direct virus–cell interactions and genes upregulated by secondary IFN production has not been made. Here, we investigated differential g...

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  • publication . Article . 2012
    Open Access English
    Authors:
    Jiang, Shibo; Lu, Lu; Du, Lanying;
    Persistent Identifiers
    Publisher: Future Medicine Ltd
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  • publication . Article . 2003
    Open Access
    Authors:
    Wu, Qingfa; Zhang, Yilin; Lu, Hong; Wang, Jing; He, Ximiao; Liu, Yong; Ye, Chen; Lin, Wei; Hu, Jianfei; Ji, Jia; ...

    None: The E (envelope) protein is the smallest structural protein in all coronaviruses and is the only viral structural protein in which no variation has been detected. We conducted genome sequencing and phylogenetic analyses of SARS-CoV. Based on genome sequencing, we ...

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  • publication . Article . 2003
    Open Access English
    Authors:
    Bi, Shengli; Qin, E’de; Xu, Zuyuan; Li, Wei; Wang, Jing; Hu, Yongwu; Liu, Yong; Duan, Shumin; Hu, Jianfei; Han, Yujun; ...
    Publisher: Beijing Institute of Genomics, the Chinese Academy of Sciences and the Genetics Society of China. Production and hosting by Elsevier B.V.

    Beijing has been one of the epicenters attacked most severely by the SARS-CoV (severe acute respiratory syndrome-associated coronavirus) since the first patient was diagnosed in one of the city’s hospitals. We now report complete genome sequences of the BJ Group, includ...

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  • publication . Article . 2003
    Open Access English
    Authors:
    Li, Jingxiang; Luo, Chunqing; Deng, Yajun; Han, Yujun; Tang, Lin; Wang, Jing; Ji, Jia; Ye, Jia; Jiang, Fanbo; Xu, Zhao; ...
    Publisher: Elsevier

    The corona-like spikes or peplomers on the surface of the virion under electronic microscope are the most striking features of coronaviruses. The S (spike) protein is the largest structural protein, with 1,255 amino acids, in the viral genome. Its structure can be divid...

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  • publication . Article . 2003
    Open Access
    Authors:
    Xu, Zuyuan; Zhang, Haiqing; Tian, Xiangjun; Ji, Jia; Li, Wei; Li, Yan; Tian, Wei; Han, Yujun; Wang, Lili; Zhang, Zizhang; ...

    The R (replicase) protein is the uniquely defined non-structural protein (NSP) responsible for RNA replication, mutation rate or fidelity, regulation of transcription in coronaviruses and many other ssRNA viruses. Based on our complete genome sequences of four isolates ...

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  • publication . Article . 2003
    Open Access English
    Authors:
    Yap, YL; Zhang, XW; Danchin, ALM;
    Persistent Identifiers
    Publisher: BMC

    BACKGROUND: The exact origin of the cause of the Severe Acute Respiratory Syndrome (SARS) is still an open question. The genomic sequence relationship of SARS-CoV with 30 different single-stranded RNA (ssRNA) viruses of various families was studied using two non-standar...

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116 research outcomes, page 1 of 12